El 9 de enero de 1988, unos científicos del Instituto Whitehead logran aislar el gen responsable del sexo humano TDF o SRY, que está localizado en el cromosoma Y, y que, por lo tanto, está presente solo en los hombres.
En los embriones masculinos, el gen SRY del cromosoma Y se activa alrededor de las semanas 6-8, dando lugar a la producción de una proteína denominada factor de la determinación testicular (TDF), esta proteína induce al tejido gonadal a formar los testículos.
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